eIF2B activator prevents neurological defects caused by a chronic integrated stress response

The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B. Vanishing White Matter (VWM) is a neurological...

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Detalles Bibliográficos
Autores principales: Wong, Yao Liang, LeBon, Lauren, Basso, Ana M, Kohlhaas, Kathy L, Nikkel, Arthur L, Robb, Holly M, Donnelly-Roberts, Diana L, Prakash, Janani, Swensen, Andrew M, Rubinstein, Nimrod D, Krishnan, Swathi, McAllister, Fiona E, Haste, Nicole V, O'Brien, Jonathon J, Roy, Margaret, Ireland, Andrea, Frost, Jennifer M, Shi, Lei, Riedmaier, Stephan, Martin, Kathleen, Dart, Michael J, Sidrauski, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326728/
https://www.ncbi.nlm.nih.gov/pubmed/30624206
http://dx.doi.org/10.7554/eLife.42940

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