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Subject specificity of the correlation between large-scale structural and functional connectivity

Structural connectivity (SC), the physical pathways connecting regions in the brain, and functional connectivity (FC), the temporal coactivations, are known to be tightly linked. However, the nature of this relationship is still not understood. In the present study, we examined this relation more cl...

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Autores principales: Zimmermann, J., Griffiths, J., Schirner, M., Ritter, P., McIntosh, A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MIT Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326745/
https://www.ncbi.nlm.nih.gov/pubmed/30793075
http://dx.doi.org/10.1162/netn_a_00055
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author Zimmermann, J.
Griffiths, J.
Schirner, M.
Ritter, P.
McIntosh, A. R.
author_facet Zimmermann, J.
Griffiths, J.
Schirner, M.
Ritter, P.
McIntosh, A. R.
author_sort Zimmermann, J.
collection PubMed
description Structural connectivity (SC), the physical pathways connecting regions in the brain, and functional connectivity (FC), the temporal coactivations, are known to be tightly linked. However, the nature of this relationship is still not understood. In the present study, we examined this relation more closely in six separate human neuroimaging datasets with different acquisition and preprocessing methods. We show that using simple linear associations, the relation between an individual’s SC and FC is not subject specific for five of the datasets. Subject specificity of SC-FC fit is achieved only for one of the six datasets, the multimodal Glasser Human Connectome Project (HCP) parcellated dataset. We show that subject specificity of SC-FC correspondence is limited across datasets due to relatively small variability between subjects in SC compared with the larger variability in FC.
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spelling pubmed-63267452019-02-21 Subject specificity of the correlation between large-scale structural and functional connectivity Zimmermann, J. Griffiths, J. Schirner, M. Ritter, P. McIntosh, A. R. Netw Neurosci Research Articles Structural connectivity (SC), the physical pathways connecting regions in the brain, and functional connectivity (FC), the temporal coactivations, are known to be tightly linked. However, the nature of this relationship is still not understood. In the present study, we examined this relation more closely in six separate human neuroimaging datasets with different acquisition and preprocessing methods. We show that using simple linear associations, the relation between an individual’s SC and FC is not subject specific for five of the datasets. Subject specificity of SC-FC fit is achieved only for one of the six datasets, the multimodal Glasser Human Connectome Project (HCP) parcellated dataset. We show that subject specificity of SC-FC correspondence is limited across datasets due to relatively small variability between subjects in SC compared with the larger variability in FC. MIT Press 2018-10-01 /pmc/articles/PMC6326745/ /pubmed/30793075 http://dx.doi.org/10.1162/netn_a_00055 Text en © 2018 Massachusetts Institute of Technology This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode.
spellingShingle Research Articles
Zimmermann, J.
Griffiths, J.
Schirner, M.
Ritter, P.
McIntosh, A. R.
Subject specificity of the correlation between large-scale structural and functional connectivity
title Subject specificity of the correlation between large-scale structural and functional connectivity
title_full Subject specificity of the correlation between large-scale structural and functional connectivity
title_fullStr Subject specificity of the correlation between large-scale structural and functional connectivity
title_full_unstemmed Subject specificity of the correlation between large-scale structural and functional connectivity
title_short Subject specificity of the correlation between large-scale structural and functional connectivity
title_sort subject specificity of the correlation between large-scale structural and functional connectivity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326745/
https://www.ncbi.nlm.nih.gov/pubmed/30793075
http://dx.doi.org/10.1162/netn_a_00055
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