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Single-molecule imaging of transcription at damaged chromatin

How DNA double-strand breaks (DSBs) affect ongoing transcription remains elusive due to the lack of single-molecule resolution tools directly measuring transcription dynamics upon DNA damage. Here, we established new reporter systems that allow the visualization of individual nascent RNAs with high...

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Detalles Bibliográficos
Autores principales:	Vítor, Alexandra C., Sridhara, Sreerama C., Sabino, João C., Afonso, Ana I., Grosso, Ana R., Martin, Robert M., de Almeida, Sérgio F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326756/ https://www.ncbi.nlm.nih.gov/pubmed/30662944 http://dx.doi.org/10.1126/sciadv.aau1249

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