TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease

The RNA-binding protein TDP-43 is heavily implicated in neurodegenerative disease. Numerous patient mutations in TARDBP, the gene encoding TDP-43, combined with data from animal and cell-based models, imply that altered RNA regulation by TDP-43 causes Amyotrophic Lateral Sclerosis and Frontotemporal...

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Detalles Bibliográficos
Autores principales: Neelagandan, Nagammal, Gonnella, Giorgio, Dang, Stefan, Janiesch, Philipp C, Miller, Katharine K, Küchler, Katrin, Marques, Rita F, Indenbirken, Daniela, Alawi, Malik, Grundhoff, Adam, Kurtz, Stefan, Duncan, Kent E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326785/
https://www.ncbi.nlm.nih.gov/pubmed/30357366
http://dx.doi.org/10.1093/nar/gky972

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