Methylation of UHRF1 by SET7 is essential for DNA double-strand break repair

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a key epigenetic regulator of DNA methylation maintenance and heterochromatin formation. The roles of UHRF1 in DNA damage repair also have been emphasized in recent years. However, the regulatory mechanism of UHRF1 remains elusive. In this...

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Detalles Bibliográficos
Autores principales: Hahm, Ja Young, Kim, Ji-Young, Park, Jin Woo, Kang, Joo-Young, Kim, Kee-Beom, Kim, Se-Ryeon, Cho, Hana, Seo, Sang-Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326791/
https://www.ncbi.nlm.nih.gov/pubmed/30357346
http://dx.doi.org/10.1093/nar/gky975

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