TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance

In human cells, telomeres are elongated by the telomerase complex that contains the reverse transcriptase hTERT and RNA template TERC/hTR. Poly(A)-specific ribonuclease (PARN) is known to trim hTR precursors by removing poly(A) tails. However, the precise mechanism of hTR 3′ maturation remains large...

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Detalles Bibliográficos
Autores principales: Deng, Tingting, Huang, Yan, Weng, Kai, Lin, Song, Li, Yujing, Shi, Guang, Chen, Yali, Huang, Junjiu, Liu, Dan, Ma, Wenbin, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA Prot Comp
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326811/
https://www.ncbi.nlm.nih.gov/pubmed/30371886
http://dx.doi.org/10.1093/nar/gky1019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326811/
https://www.ncbi.nlm.nih.gov/pubmed/30371886
http://dx.doi.org/10.1093/nar/gky1019

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