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A dual-functional priming-capping loop of rhabdoviral RNA polymerases directs terminal de novo initiation and capping intermediate formation

The L proteins of rhabdoviruses, such as vesicular stomatitis virus (VSV) and rabies virus (RABV), possess an unconventional mRNA capping enzyme (GDP polyribonucleotidyltransferase, PRNTase) domain with a loop structure protruding into an active site cavity of the RNA-dependent RNA polymerase (RdRp)...

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Detalles Bibliográficos
Autores principales:	Ogino, Minako, Gupta, Nirmala, Green, Todd J, Ogino, Tomoaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326812/ https://www.ncbi.nlm.nih.gov/pubmed/30395342 http://dx.doi.org/10.1093/nar/gky1058

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