Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases

Metallo‐β‐Lactamases (MBLs) protect bacteria from almost all β‐lactam antibiotics. Verona integron‐encoded MBL (VIM) enzymes are among the most clinically important MBLs, with VIM‐1 increasing in carbapenem‐resistant Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae) that are among the har...

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Detalles Bibliográficos
Autores principales: Salimraj, Ramya, Hinchliffe, Philip, Kosmopoulou, Magda, Tyrrell, Jonathan M., Brem, Jürgen, van Berkel, Sander S., Verma, Anil, Owens, Raymond J., McDonough, Michael A., Walsh, Timothy R., Schofield, Christopher J., Spencer, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326847/
https://www.ncbi.nlm.nih.gov/pubmed/30430727
http://dx.doi.org/10.1111/febs.14695

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