A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives

Clinical data acquired over the last decade on non-small cell lung cancer (NSCLC) treatment with small molecular weight Epidermal Growth Factor Receptor (EGFR) inhibitors have shown significant influence of EGFR point mutations and in-frame deletions on clinical efficacy. Identification of small mol...

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Detalles Bibliográficos
Autores principales: do Amaral, Daniel Nascimento, Lategahn, Jonas, Fokoue, Harold Hilarion, da Silva, Eduardo Miguez Bastos, Sant’Anna, Carlos Mauricio R., Rauh, Daniel, Barreiro, Eliezer J., Laufer, Stefan, Lima, Lidia Moreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327040/
https://www.ncbi.nlm.nih.gov/pubmed/30626888
http://dx.doi.org/10.1038/s41598-018-36846-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327040/
https://www.ncbi.nlm.nih.gov/pubmed/30626888
http://dx.doi.org/10.1038/s41598-018-36846-7

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