The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α(1)-adrenoceptor

SUL-compounds are protectants from cold-induced ischemia and mitochondrial dysfunction. We discovered that adding SUL-121 to renal grafts during warm machine reperfusion elicits a rapid improvement in perfusion parameters. Therefore, we investigate the molecular mechanisms of action in porcine intra...

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Detalles Bibliográficos
Autores principales: Nakladal, D., Buikema, H., Romero, A. Reyes, Lambooy, S. P. H., Bouma, J., Krenning, G., Vogelaar, P., van der Graaf, A. C., Groves, M. R., Kyselovic, J., Henning, R. H., Deelman, L. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327096/
https://www.ncbi.nlm.nih.gov/pubmed/30626882
http://dx.doi.org/10.1038/s41598-018-36788-0

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