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Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer

Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic proper...

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Autores principales: Kang, Jingjing, Zhang, Li, Luo, Xiao, Ma, Xiangyu, Wang, Gaoying, Yang, Yanhui, Yan, Yongmin, Qian, Hui, Zhang, Xu, Xu, Wenrong, Mao, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327253/
https://www.ncbi.nlm.nih.gov/pubmed/30687760
http://dx.doi.org/10.1155/2018/9652817
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author Kang, Jingjing
Zhang, Li
Luo, Xiao
Ma, Xiangyu
Wang, Gaoying
Yang, Yanhui
Yan, Yongmin
Qian, Hui
Zhang, Xu
Xu, Wenrong
Mao, Fei
author_facet Kang, Jingjing
Zhang, Li
Luo, Xiao
Ma, Xiangyu
Wang, Gaoying
Yang, Yanhui
Yan, Yongmin
Qian, Hui
Zhang, Xu
Xu, Wenrong
Mao, Fei
author_sort Kang, Jingjing
collection PubMed
description Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD. The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions. One of the promising therapeutic options for IBD can focus on exosomes of MSCs. MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition. Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved. This review can assist investigators better to understand the research progress for enhancing the efficacy of MSCs therapy involved in IBD and CAC.
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spelling pubmed-63272532019-01-27 Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer Kang, Jingjing Zhang, Li Luo, Xiao Ma, Xiangyu Wang, Gaoying Yang, Yanhui Yan, Yongmin Qian, Hui Zhang, Xu Xu, Wenrong Mao, Fei Biomed Res Int Review Article Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD. The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions. One of the promising therapeutic options for IBD can focus on exosomes of MSCs. MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition. Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved. This review can assist investigators better to understand the research progress for enhancing the efficacy of MSCs therapy involved in IBD and CAC. Hindawi 2018-12-26 /pmc/articles/PMC6327253/ /pubmed/30687760 http://dx.doi.org/10.1155/2018/9652817 Text en Copyright © 2018 Jingjing Kang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kang, Jingjing
Zhang, Li
Luo, Xiao
Ma, Xiangyu
Wang, Gaoying
Yang, Yanhui
Yan, Yongmin
Qian, Hui
Zhang, Xu
Xu, Wenrong
Mao, Fei
Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_full Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_fullStr Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_full_unstemmed Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_short Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
title_sort systematic exposition of mesenchymal stem cell for inflammatory bowel disease and its associated colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327253/
https://www.ncbi.nlm.nih.gov/pubmed/30687760
http://dx.doi.org/10.1155/2018/9652817
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