Suppression of cathepsin K biomarker in synovial fluid as a free-drug–driven process

Cathepsin K (CatK) inhibitors exhibited chondroprotective and pain-reducing effects in animal models, however, improvements were relatively modest at dose levels achieving maximal suppression of CatK biomarkers in urine. In this report, a previously characterized CatK inhibitor (MK-1256) is utilized...

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Detalles Bibliográficos
Autores principales: Ma, Bennett, Wesolowski, Gregg, Luo, Bin, Lifsted, Traci, Wessner, Keith, Adamson, Gary, Glantschnig, Helmut, Lubbers, Laura S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327326/
https://www.ncbi.nlm.nih.gov/pubmed/30671145
http://dx.doi.org/10.1177/1849454418821819

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