Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage

BACKGROUND: The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesophageal reflux disease (GERD). Exposure of BE and EAC cells to acidic bile salts...

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Detalles Bibliográficos
Autores principales: Zhou, Zhangjian, Lu, Heng, Zhu, Shoumin, Gomaa, Ahmed, Chen, Zheng, Yan, Jin, Washington, Kay, El-Rifai, Wael, Dang, Chengxue, Peng, Dunfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327430/
https://www.ncbi.nlm.nih.gov/pubmed/30626422
http://dx.doi.org/10.1186/s13046-018-1021-y

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