Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation

Paraquat (PQ) intoxication causes thousands of mortalities every year, worldwide. Its pulmonary-targeted accumulation and the acute lung injury it subsequently causes, remain a challenge for detoxification treatment. A previous study has demonstrated that the upregulation of nuclear factor erythroid...

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Detalles Bibliográficos
Autores principales: Wu, Bin, Li, Hai-Xiao, Lian, Jie, Guo, Yong-Jie, Tang, Ya-Hui, Chang, Zi-Juan, Hu, Lu-Feng, Zhao, Guang-Ju, Hong, Guang-Liang, Lu, Zhong-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327482/
https://www.ncbi.nlm.nih.gov/pubmed/30679998
http://dx.doi.org/10.3892/etm.2018.7044

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