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An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations
BACKGROUND: The benefit of a given treatment can be evaluated via a randomized clinical trial design. However, protocol deviations may severely compromise treatment effect since such deviations often lead to missing values. The assumption that methods of analysis can account for the missing data can...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327569/ https://www.ncbi.nlm.nih.gov/pubmed/30626328 http://dx.doi.org/10.1186/s12874-018-0639-y |