Cargando…

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation

Platelet activators stimulate post-translational modification of signalling proteins to change their activity or their molecular interactions leading to signal propagation. One covalent modification is attachment of the small protein ubiquitin to lysine residues in target proteins. Modification by u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Unsworth, Amanda J., Bombik, Izabela, Pinto-Fernandez, Adan, McGouran, Joanna F., Konietzny, Rebecca, Zahedi, René P., Watson, Steve P., Kessler, Benedikt M., Pears, Catherine J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Georg Thieme Verlag KG 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327716/ https://www.ncbi.nlm.nih.gov/pubmed/30597505 http://dx.doi.org/10.1055/s-0038-1676344

Ejemplares similares

Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System
por: Perrella, Gina, et al.
Publicado: (2021)

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation
por: Neagoe, Raluca A. I., et al.
Publicado: (2022)

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
por: Billiald, Philippe, et al.
Publicado: (2022)

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
por: Poulter, N. S., et al.
Publicado: (2017)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19
por: Vere, George, et al.
Publicado: (2022)

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation
por: Jooss, Natalie J., et al.
Publicado: (2022)

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation
por: Haining, Elizabeth J., et al.
Publicado: (2016)

GPVI expression is linked to platelet size, age, and reactivity
por: Veninga, Alicia, et al.
Publicado: (2022)

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
por: Blackledge, Neil P., et al.
Publicado: (2014)

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood
por: Jung, Stephanie M., et al.
Publicado: (2012)

DNA Modification under Mild Conditions by Suzuki–Miyaura Cross-Coupling for the Generation of Functional Probes**
por: Lercher, Lukas, et al.
Publicado: (2013)

Comparison of the GPVI inhibitors losartan and honokiol
por: Onselaer, Marie-Blanche, et al.
Publicado: (2019)

mTOR regulates GPVI-mediated platelet activation
por: Wang, Longsheng, et al.
Publicado: (2021)

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation
por: Akbar, Huzoor, et al.
Publicado: (2011)

Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes
por: McGouran, Joanna F., et al.
Publicado: (2013)

Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies
por: Jamasbi, Janina, et al.
Publicado: (2015)

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains
por: Protty, Majd B., et al.
Publicado: (2008)

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation()
por: Walsh, T.G., et al.
Publicado: (2014)

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice
por: Eaton, Nathan, et al.
Publicado: (2020)

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI
por: Kaiser, Rainer, et al.
Publicado: (2022)

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis
por: Ye, Yujia, et al.
Publicado: (2023)

Evaluation of the effect of eltrombopag therapy on the platelet collagen receptor glycoprotein VI (GPVI) expression and soluble GPVI levels in young patients with immune thrombocytopenia
por: Tantawy, Azza Abdel Gawad, et al.
Publicado: (2022)

Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
por: Taylor, Neil C., et al.
Publicado: (2020)

Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A
por: Dürr, Eva-Maria, et al.
Publicado: (2021)

Modern Doctoring
por: McGouran, Rory C
Publicado: (2000)

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation
por: Moraes, L A, et al.
Publicado: (2010)

Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia
por: Hardy, Alexander T., et al.
Publicado: (2018)

Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation
por: Nestele, Jeremy A., et al.
Publicado: (2021)

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets
por: Zhou, Jing, et al.
Publicado: (2020)

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1
por: De Simone, Ilaria, et al.
Publicado: (2022)

The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner
por: Hoermann, Henrike, et al.
Publicado: (2021)

The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo
por: Bogani, Debora, et al.
Publicado: (2013)

MMP‐13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation
por: Howes, Joanna‐Marie, et al.
Publicado: (2018)

Glaucocalyxin A Inhibits Platelet Activation and Thrombus Formation Preferentially via GPVI Signaling Pathway
por: Li, Wei, et al.
Publicado: (2013)

A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
por: Shih, Tzenge‐Lien, et al.
Publicado: (2021)

Flipping the Switch: Innovations in Inducible Probes for Protein Profiling
por: McKenna, Sean M., et al.
Publicado: (2021)

GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region
por: Xu, Rui-Gang, et al.
Publicado: (2021)

Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease
por: Pennings, Gabrielle J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rt3cj2ufq1ntn1gtgf4pliug14