Bacteria-free minicircle DNA system to generate integration-free CAR-T cells

BACKGROUND: Chimeric antigen receptor T (CAR-T) cells engineered with lentiviral and retroviral vectors have been successfully applied to treat patients with B cell malignancy. However, viral integration in T cells has the potential risk of mutagenesis, and viral vector production demands effort and...

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Detalles Bibliográficos
Autores principales: Cheng, Chen, Tang, Na, Li, Jiaxin, Cao, Shiwei, Zhang, Tongtong, Wei, Xiaofei, Wang, Haoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327863/
https://www.ncbi.nlm.nih.gov/pubmed/30030293
http://dx.doi.org/10.1136/jmedgenet-2018-105405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327863/
https://www.ncbi.nlm.nih.gov/pubmed/30030293
http://dx.doi.org/10.1136/jmedgenet-2018-105405

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