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Bacteria-free minicircle DNA system to generate integration-free CAR-T cells
BACKGROUND: Chimeric antigen receptor T (CAR-T) cells engineered with lentiviral and retroviral vectors have been successfully applied to treat patients with B cell malignancy. However, viral integration in T cells has the potential risk of mutagenesis, and viral vector production demands effort and...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BMJ Publishing Group
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327863/ https://www.ncbi.nlm.nih.gov/pubmed/30030293 http://dx.doi.org/10.1136/jmedgenet-2018-105405 |