A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

Mitochondria play important roles in the development of diabetic kidney disease (DKD). The SS peptide is a tetrapeptide that is located and accumulated in the inner mitochondrial membrane; it reduces reactive oxygen species (ROS) and prevents mitochondrial dysfunction. Podocytes are key cellular com...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoqiao, Tang, Dongdong, Zou, Yaowei, Wu, Xiaoyu, Chen, Yihua, Li, Hongying, Chen, Siqi, Shi, Yue, Niu, Hongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327984/
https://www.ncbi.nlm.nih.gov/pubmed/30734599
http://dx.doi.org/10.1080/14756366.2018.1488697

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