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Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice
OBJECTIVE: Prg4, also known as Lubricin, acts as a joint/boundary lubricant. Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice. Surgically induced OA serves as a good model for post-traumatic OA but is not ideal for recapitulating age-related OA. Reduced expression of the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328116/ https://www.ncbi.nlm.nih.gov/pubmed/30629676 http://dx.doi.org/10.1371/journal.pone.0210601 |