ATP in the tumour microenvironment drives expression of nfP2X(7), a key mediator of cancer cell survival

The ATP-gated receptor P2X(7) is expressed in multiple malignant tumours including neuroblastoma, melanoma, prostate, lung and breast. P2X(7) has a significant role in mediating diverse cell responses, which upon dysregulation are associated with tumour initiation and development. The rapid, ATP-med...

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Detalles Bibliográficos
Autores principales: Gilbert, SM, Oliphant, CJ, Hassan, S., Peille, AL, Bronsert, P., Falzoni, S., Di Virgilio, F., McNulty, S., Lara, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328436/
https://www.ncbi.nlm.nih.gov/pubmed/30087439
http://dx.doi.org/10.1038/s41388-018-0426-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328436/
https://www.ncbi.nlm.nih.gov/pubmed/30087439
http://dx.doi.org/10.1038/s41388-018-0426-6

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