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Maternal Adiposity Influences Neonatal Brain Functional Connectivity
The neural mechanisms associated with obesity have been extensively studied, but the impact of maternal obesity on fetal and neonatal brain development remains poorly understood. In this study of full-term neonates, we aimed to detect potential neonatal functional connectivity alterations associated...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328446/ https://www.ncbi.nlm.nih.gov/pubmed/30662399 http://dx.doi.org/10.3389/fnhum.2018.00514 |
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author | Salzwedel, Andrew P. Gao, Wei Andres, Aline Badger, Thomas M. Glasier, Charles M. Ramakrishnaiah, Raghu H. Rowell, Amy C. Ou, Xiawei |
author_facet | Salzwedel, Andrew P. Gao, Wei Andres, Aline Badger, Thomas M. Glasier, Charles M. Ramakrishnaiah, Raghu H. Rowell, Amy C. Ou, Xiawei |
author_sort | Salzwedel, Andrew P. |
collection | PubMed |
description | The neural mechanisms associated with obesity have been extensively studied, but the impact of maternal obesity on fetal and neonatal brain development remains poorly understood. In this study of full-term neonates, we aimed to detect potential neonatal functional connectivity alterations associated with maternal adiposity, quantified via body-mass-index (BMI) and body-fat-mass (BFM) percentage, based on seed-based and graph theoretical analysis using resting-state fMRI data. Our results revealed significant neonatal functional connectivity alterations in all four functional domains that are implicated in adult obesity: sensory cue processing, reward processing, cognitive control, and motor control. Moreover, some of the detected areas showing regional functional connectivity alterations also showed global degree and efficiency differences. These findings provide important clues to the potential neural basis for cognitive and mental health development in offspring of obese mothers and may lead to the derivation of imaging-based biomarkers for the early identification of risks for timely intervention. |
format | Online Article Text |
id | pubmed-6328446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63284462019-01-18 Maternal Adiposity Influences Neonatal Brain Functional Connectivity Salzwedel, Andrew P. Gao, Wei Andres, Aline Badger, Thomas M. Glasier, Charles M. Ramakrishnaiah, Raghu H. Rowell, Amy C. Ou, Xiawei Front Hum Neurosci Neuroscience The neural mechanisms associated with obesity have been extensively studied, but the impact of maternal obesity on fetal and neonatal brain development remains poorly understood. In this study of full-term neonates, we aimed to detect potential neonatal functional connectivity alterations associated with maternal adiposity, quantified via body-mass-index (BMI) and body-fat-mass (BFM) percentage, based on seed-based and graph theoretical analysis using resting-state fMRI data. Our results revealed significant neonatal functional connectivity alterations in all four functional domains that are implicated in adult obesity: sensory cue processing, reward processing, cognitive control, and motor control. Moreover, some of the detected areas showing regional functional connectivity alterations also showed global degree and efficiency differences. These findings provide important clues to the potential neural basis for cognitive and mental health development in offspring of obese mothers and may lead to the derivation of imaging-based biomarkers for the early identification of risks for timely intervention. Frontiers Media S.A. 2019-01-04 /pmc/articles/PMC6328446/ /pubmed/30662399 http://dx.doi.org/10.3389/fnhum.2018.00514 Text en Copyright © 2019 Salzwedel, Gao, Andres, Badger, Glasier, Ramakrishnaiah, Rowell and Ou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Salzwedel, Andrew P. Gao, Wei Andres, Aline Badger, Thomas M. Glasier, Charles M. Ramakrishnaiah, Raghu H. Rowell, Amy C. Ou, Xiawei Maternal Adiposity Influences Neonatal Brain Functional Connectivity |
title | Maternal Adiposity Influences Neonatal Brain Functional Connectivity |
title_full | Maternal Adiposity Influences Neonatal Brain Functional Connectivity |
title_fullStr | Maternal Adiposity Influences Neonatal Brain Functional Connectivity |
title_full_unstemmed | Maternal Adiposity Influences Neonatal Brain Functional Connectivity |
title_short | Maternal Adiposity Influences Neonatal Brain Functional Connectivity |
title_sort | maternal adiposity influences neonatal brain functional connectivity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328446/ https://www.ncbi.nlm.nih.gov/pubmed/30662399 http://dx.doi.org/10.3389/fnhum.2018.00514 |
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