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Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with nuclear antigens or apoptotic cells. Since un...
Autores principales: | Lloyd, Katy A., Wigerblad, Gustaf, Sahlström, Peter, Garimella, Manasa G., Chemin, Karine, Steen, Johanna, Titcombe, Philip J., Marklein, Bianka, Zhou, Diana, Stålesen, Ragnhild, Ossipova, Elena, Lundqvist, Christina, Ekwall, Olov, Rönnelid, Johan, Mueller, Daniel L., Karlsson, Mikael C. I., Kaplan, Mariana J., Skriner, Karl, Klareskog, Lars, Wermeling, Fredrik, Malmström, Vivianne, Grönwall, Caroline |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328449/ https://www.ncbi.nlm.nih.gov/pubmed/30662440 http://dx.doi.org/10.3389/fimmu.2018.03033 |
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