Cargando…

CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression

Caudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear transcription factor, has been strongly implicated in the tumourigenesis of various human cancers. However, the functional role of CDX2 in the development and progression of colorectal cancer (CRC) is not well known...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Junhui, Liu, Dong, Sun, Xuejun, Yang, Kui, Yao, Jianfeng, Cheng, Chen, Wang, Chunbao, Zheng, Jianbao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328578/ https://www.ncbi.nlm.nih.gov/pubmed/30631044 http://dx.doi.org/10.1038/s41419-018-1263-9

Ejemplares similares

CDX2 inhibits epithelial–mesenchymal transition in colorectal cancer by modulation of Snail expression and β-catenin stabilisation via transactivation of PTEN expression
por: Yu, Junhui, et al.
Publicado: (2020)

Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of β-catenin
por: Xu, Zhengshui, et al.
Publicado: (2021)

Expression of β-catenin and AXIN2 in ameloblastomas
por: Wei, Zhenhui, et al.
Publicado: (2013)

Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
por: Yu, Junhui, et al.
Publicado: (2020)

An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
por: Bernkopf, Dominic B., et al.
Publicado: (2019)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo
por: Zheng, Jianbao, et al.
Publicado: (2017)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
por: Ji, Lei, et al.
Publicado: (2019)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin
por: Chinison, Jessica, et al.
Publicado: (2016)

Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway
por: Chen, Lianqi, et al.
Publicado: (2023)

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction
por: Pronobis, Mira I, et al.
Publicado: (2015)

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway
por: Wang, Yuting, et al.
Publicado: (2022)

Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
por: Thorvaldsen, Tor Espen, et al.
Publicado: (2017)

Activation of FXR and inhibition of EZH2 synergistically inhibit colorectal cancer through cooperatively accelerating FXR nuclear location and upregulating CDX2 expression
por: Yu, Junhui, et al.
Publicado: (2022)

JARID1B promotes colorectal cancer proliferation and Wnt/β-catenin signaling via decreasing CDX2 level
por: Huang, Da, et al.
Publicado: (2020)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
por: Chen, Hsin-Yi, et al.
Publicado: (2019)

Correction: Activation of FXR and inhibition of EZH2 synergistically inhibit colorectal cancer through cooperatively accelerating FXR nuclear location and upregulating CDX2 expression
por: Yu, Junhui, et al.
Publicado: (2023)

LncRNA GAS5 regulates the Wnt/β-catenin pathway through the miR-18a-5p/AXIN2/GSK3β axis to inhibit the proliferation and migration of bladder cancer cells
por: Zhang, Ze, et al.
Publicado: (2022)

TRIM37 promotes gallbladder cancer proliferation by activating the Wnt/β-catenin pathway via ubiquitination of Axin1
por: Xu, Ming, et al.
Publicado: (2023)

Phase separation of Axin organizes the β-catenin destruction complex
por: Nong, Junxiu, et al.
Publicado: (2021)

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation
por: Ji, Lei, et al.
Publicado: (2017)

Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth
por: Miete, Cezanne, et al.
Publicado: (2022)

CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways
por: Fan, Hong-Bo, et al.
Publicado: (2017)

SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer
por: Liu, Huidi, et al.
Publicado: (2016)

Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
por: Babb, Rebecca, et al.
Publicado: (2017)

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β
por: Gao, Chenxi, et al.
Publicado: (2015)

Wnt/Axin1/β-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries
por: Carl, Matthias, et al.
Publicado: (2007)

Aberrant nuclear localization of β-catenin without genetic alterations in β-catenin or Axin genes in esophageal cancer
por: Kudo, Junzo, et al.
Publicado: (2007)

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
por: Peng, Yin, et al.
Publicado: (2021)

20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway
por: Lin, Kaili, et al.
Publicado: (2020)

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition
por: Gavagan, Maire, et al.
Publicado: (2023)

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta
por: Martino-Echarri, Estefania, et al.
Publicado: (2016)

Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/β-Catenin Pathway
por: Jiang, Xinger, et al.
Publicado: (2019)

The Expression of Selected Wnt Pathway Members (FZD6, AXIN2 and β-Catenin) in Canine Oral Squamous Cell Carcinoma and Acanthomatous Ameloblastoma
por: Putnová, Barbora, et al.
Publicado: (2021)

Wnt-signalling pathway in ovarian epithelial tumours: increased expression of β-catenin and GSK3β
por: Rask, K, et al.
Publicado: (2003)

RNA m(6)A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling
por: Li, Yin, et al.
Publicado: (2021)

CCAAT/enhancer-binding protein-β functions as a negative regulator of Wnt/β-catenin signaling through activation of AXIN1 gene expression
por: Park, Seoyoung, et al.
Publicado: (2018)

Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
por: Babcock, Rachel L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mc222ol0rdv22csjmkol42b6bt