Inhibition of HGF/MET signaling decreases overall tumor burden and blocks malignant conversion in Tpl2-related skin cancer

Tumor progression locus 2 (Tpl2) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family of serine/threonine kinases. Deletion of the Tpl2 gene is associated with a significantly higher number of papillomas and cutaneous squamous cell carcinomas (cSCCs). Overexpression of he...

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Detalles Bibliográficos
Autores principales: Bonan, Nicole F., Kowalski, David, Kudlac, Kaitie, Flaherty, Kira, Gwilliam, J. Curtis, Falkenberg, Lauren G., Maradiaga, Erik, DeCicco-Skinner, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328619/
https://www.ncbi.nlm.nih.gov/pubmed/30631034
http://dx.doi.org/10.1038/s41389-018-0109-8

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