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Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stability

Clear cell renal cell carcinoma (ccRCC) is intimately associated with defects in ubiquitin-mediated protein degradation. Herein, we report that deficiency in the E3 ligase subunit cullin 5 (CUL5) promotes chromosomal instability and is an independent negative prognostic factor in ccRCC. CUL5 was ini...

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Detalles Bibliográficos
Autores principales:	Tapia-Laliena, María Ángeles, Korzeniewski, Nina, Peña-Llopis, Samuel, Scholl, Claudia, Fröhling, Stefan, Hohenfellner, Markus, Duensing, Anette, Duensing, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328621/ https://www.ncbi.nlm.nih.gov/pubmed/30631037 http://dx.doi.org/10.1038/s41389-018-0110-2

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