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Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis
Background: Recently, the roles of tumor necrosis factor-α (TNF-α) polymorphisms in colorectal cancer (CRC) were analyzed by some pilot studies, with inconsistent results. Therefore, we performed the present study to better assess the relationship between TNF-α polymorphisms and the risk of CRC. Met...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328862/ https://www.ncbi.nlm.nih.gov/pubmed/30509966 http://dx.doi.org/10.1042/BSR20181750 |
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author | Huang, Xue Qin, Shanyu Liu, Yongru Tao, Lin Jiang, Haixing |
author_facet | Huang, Xue Qin, Shanyu Liu, Yongru Tao, Lin Jiang, Haixing |
author_sort | Huang, Xue |
collection | PubMed |
description | Background: Recently, the roles of tumor necrosis factor-α (TNF-α) polymorphisms in colorectal cancer (CRC) were analyzed by some pilot studies, with inconsistent results. Therefore, we performed the present study to better assess the relationship between TNF-α polymorphisms and the risk of CRC. Methods: Eligible studies were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess correlations between TNF-α polymorphisms and CRC. Results: A total of 22 studies were included for analyses. A significant association with the risk of CRC was detected for TNF-α -308 G/A (recessive model: P = 0.004, OR = 1.42, 95%CI 1.12–1.79) polymorphism in overall analyses. Further subgroup analyses based on ethnicity of participants revealed that TNF-α -238 G/A was significantly correlated with the risk of CRC in Caucasians (dominant model: P = 0.01, OR = 0.47, 95%CI 0.26–0.86; overdominant model: P = 0.01, OR = 2.27, 95%CI 1.20–4.30; allele model: P = 0.02, OR = 0.51, 95%CI 0.29–0.90), while -308 G/A polymorphism was significantly correlated with the risk of CRC in Asians (recessive model: P = 0.001, OR = 2.23, 95%CI 1.38–3.63). Conclusions: Our findings indicated that TNF-α -238 G/A polymorphism may serve as a potential biological marker for CRC in Caucasians, and TNF-α -308 G/A polymorphism may serve as a potential biological marker for CRC in Asians. |
format | Online Article Text |
id | pubmed-6328862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63288622019-01-18 Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis Huang, Xue Qin, Shanyu Liu, Yongru Tao, Lin Jiang, Haixing Biosci Rep Research Articles Background: Recently, the roles of tumor necrosis factor-α (TNF-α) polymorphisms in colorectal cancer (CRC) were analyzed by some pilot studies, with inconsistent results. Therefore, we performed the present study to better assess the relationship between TNF-α polymorphisms and the risk of CRC. Methods: Eligible studies were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess correlations between TNF-α polymorphisms and CRC. Results: A total of 22 studies were included for analyses. A significant association with the risk of CRC was detected for TNF-α -308 G/A (recessive model: P = 0.004, OR = 1.42, 95%CI 1.12–1.79) polymorphism in overall analyses. Further subgroup analyses based on ethnicity of participants revealed that TNF-α -238 G/A was significantly correlated with the risk of CRC in Caucasians (dominant model: P = 0.01, OR = 0.47, 95%CI 0.26–0.86; overdominant model: P = 0.01, OR = 2.27, 95%CI 1.20–4.30; allele model: P = 0.02, OR = 0.51, 95%CI 0.29–0.90), while -308 G/A polymorphism was significantly correlated with the risk of CRC in Asians (recessive model: P = 0.001, OR = 2.23, 95%CI 1.38–3.63). Conclusions: Our findings indicated that TNF-α -238 G/A polymorphism may serve as a potential biological marker for CRC in Caucasians, and TNF-α -308 G/A polymorphism may serve as a potential biological marker for CRC in Asians. Portland Press Ltd. 2019-01-11 /pmc/articles/PMC6328862/ /pubmed/30509966 http://dx.doi.org/10.1042/BSR20181750 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Huang, Xue Qin, Shanyu Liu, Yongru Tao, Lin Jiang, Haixing Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
title | Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
title_full | Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
title_fullStr | Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
title_full_unstemmed | Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
title_short | Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
title_sort | associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328862/ https://www.ncbi.nlm.nih.gov/pubmed/30509966 http://dx.doi.org/10.1042/BSR20181750 |
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