Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hyperten...

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Detalles Bibliográficos
Autores principales: Wu, Chia-Hua, Wang, Ya, Ma, Murong, Mullick, Adam E., Crooke, Rosanne M., Graham, Mark J., Daugherty, Alan, Lu, Hong S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328882/
https://www.ncbi.nlm.nih.gov/pubmed/30530571
http://dx.doi.org/10.1042/BSR20180201
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author Wu, Chia-Hua
Wang, Ya
Ma, Murong
Mullick, Adam E.
Crooke, Rosanne M.
Graham, Mark J.
Daugherty, Alan
Lu, Hong S.
author_facet Wu, Chia-Hua
Wang, Ya
Ma, Murong
Mullick, Adam E.
Crooke, Rosanne M.
Graham, Mark J.
Daugherty, Alan
Lu, Hong S.
author_sort Wu, Chia-Hua
collection PubMed
description Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT.
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spelling pubmed-63288822019-01-18 Antisense oligonucleotides targeting angiotensinogen: insights from animal studies Wu, Chia-Hua Wang, Ya Ma, Murong Mullick, Adam E. Crooke, Rosanne M. Graham, Mark J. Daugherty, Alan Lu, Hong S. Biosci Rep Review Articles Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT. Portland Press Ltd. 2019-01-11 /pmc/articles/PMC6328882/ /pubmed/30530571 http://dx.doi.org/10.1042/BSR20180201 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Wu, Chia-Hua
Wang, Ya
Ma, Murong
Mullick, Adam E.
Crooke, Rosanne M.
Graham, Mark J.
Daugherty, Alan
Lu, Hong S.
Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
title Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
title_full Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
title_fullStr Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
title_full_unstemmed Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
title_short Antisense oligonucleotides targeting angiotensinogen: insights from animal studies
title_sort antisense oligonucleotides targeting angiotensinogen: insights from animal studies
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328882/
https://www.ncbi.nlm.nih.gov/pubmed/30530571
http://dx.doi.org/10.1042/BSR20180201
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