Cargando…

Fulminant pseudomembranous enterocolitis caused by Klebsiella oxytoca: an autopsy case report

CASE: We describe a rare case of antibiotic‐associated fulminant pseudomembranous enterocolitis caused by Klebsiella oxytoca. A 79‐year‐old man with a history of antibiotic therapy was admitted to our emergency department, complaining of consciousness disturbance. Initially, we suspected septic shoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagamura, Tatsunori, Tanaka, Yoshihiro, Terayama, Takero, Higashiyama, Daishi, Seno, Soichiro, Isoi, Naoaki, Katsurada, Yuka, Matsubara, Akiko, Yoshimura, Yuya, Sekine, Yasumasa, Akitomi, Shinji, Sato, Kimiya, Tsuda, Hitoshi, Saitoh, Daizoh, Ikeuchi, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328918/
https://www.ncbi.nlm.nih.gov/pubmed/30652002
http://dx.doi.org/10.1002/ams2.370
Descripción
Sumario:CASE: We describe a rare case of antibiotic‐associated fulminant pseudomembranous enterocolitis caused by Klebsiella oxytoca. A 79‐year‐old man with a history of antibiotic therapy was admitted to our emergency department, complaining of consciousness disturbance. Initially, we suspected septic shock and diabetic ketoacidosis caused by intestinal infection. Although we administered sufficient extracellular fluid, his blood pressure was not elevated and his abdomen gradually swelled. OUTCOME: The patient died of shock and abdominal compartment syndrome. Autopsy revealed widespread jejunal necrosis in conjunction with colitis, suggesting fulminant pseudomembranous enterocolitis caused by K. oxytoca infection. CONCLUSION: As the clinical features of pseudomembranous enterocolitis caused by K. oxytoca resemble the features of colitis caused by Clostridium difficile, conservative therapy is applied first. However, fulminant pseudomembranous enterocolitis is a lethal disease, necessitating early operation for resection of the necrotic lesion. This report highlights the need for better surgical criteria at an early stage.