Cargando…
Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
Developed over six decades ago, pulmonary oscillometry has re‐emerged as a noninvasive and effort‐independent method for evaluating respiratory‐system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized (3)He ventilation‐defect‐percent (VD...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328923/ https://www.ncbi.nlm.nih.gov/pubmed/30632309 http://dx.doi.org/10.14814/phy2.13955 |
_version_ | 1783386733444857856 |
---|---|
author | Eddy, Rachel L. Westcott, Andrew Maksym, Geoffrey N. Parraga, Grace Dandurand, Ronald J. |
author_facet | Eddy, Rachel L. Westcott, Andrew Maksym, Geoffrey N. Parraga, Grace Dandurand, Ronald J. |
author_sort | Eddy, Rachel L. |
collection | PubMed |
description | Developed over six decades ago, pulmonary oscillometry has re‐emerged as a noninvasive and effort‐independent method for evaluating respiratory‐system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized (3)He ventilation‐defect‐percent (VDP) and respiratory‐system resistance, reactance and reactance area (A(X)) measurements in 175 participants including 42 never‐smokers without respiratory disease, 56 ex‐smokers with chronic‐obstructive‐pulmonary‐disease (COPD), 28 ex‐smokers without COPD and 49 asthmatic never‐smokers. COPD participants were dichotomized based on x‐ray computed‐tomography (CT) evidence of emphysema (relative‐area CT‐density‐histogram ≤ 950HU (RA (950)) ≥ 6.8%). In asthma and COPD subgroups, MRI VDP was significantly related to the frequency‐dependence of resistance (R (5‐19); asthma: ρ = 0.48, P = 0.0005; COPD: ρ = 0.45, P = 0.0004), reactance at 5 Hz (X (5): asthma, ρ = −0.41, P = 0.004; COPD: ρ = −0.38, P = 0.004) and A(X) (asthma: ρ = 0.47, P = 0.0007; COPD: ρ = 0.43, P = 0.0009). MRI VDP was also significantly related to R (5‐19) in COPD participants without emphysema (ρ = 0.54, P = 0.008), and to X (5) in COPD participants with emphysema (ρ = −0.36, P = 0.04). A(X) was weakly related to VDP in asthma (ρ = 0.47, P = 0.0007) and COPD participants with (ρ = 0.39, P = 0.02) and without (ρ = 0.43, P = 0.04) emphysema. A(X) is sensitive to obstruction but not specific to the type of obstruction, whereas the different relationships for MRI VDP with R (5‐19) and X (5) may reflect the different airway and parenchymal disease‐specific biomechanical abnormalities that lead to ventilation defects. |
format | Online Article Text |
id | pubmed-6328923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63289232019-01-16 Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD Eddy, Rachel L. Westcott, Andrew Maksym, Geoffrey N. Parraga, Grace Dandurand, Ronald J. Physiol Rep Original Research Developed over six decades ago, pulmonary oscillometry has re‐emerged as a noninvasive and effort‐independent method for evaluating respiratory‐system impedance in patients with obstructive lung disease. Here, we evaluated the relationships between hyperpolarized (3)He ventilation‐defect‐percent (VDP) and respiratory‐system resistance, reactance and reactance area (A(X)) measurements in 175 participants including 42 never‐smokers without respiratory disease, 56 ex‐smokers with chronic‐obstructive‐pulmonary‐disease (COPD), 28 ex‐smokers without COPD and 49 asthmatic never‐smokers. COPD participants were dichotomized based on x‐ray computed‐tomography (CT) evidence of emphysema (relative‐area CT‐density‐histogram ≤ 950HU (RA (950)) ≥ 6.8%). In asthma and COPD subgroups, MRI VDP was significantly related to the frequency‐dependence of resistance (R (5‐19); asthma: ρ = 0.48, P = 0.0005; COPD: ρ = 0.45, P = 0.0004), reactance at 5 Hz (X (5): asthma, ρ = −0.41, P = 0.004; COPD: ρ = −0.38, P = 0.004) and A(X) (asthma: ρ = 0.47, P = 0.0007; COPD: ρ = 0.43, P = 0.0009). MRI VDP was also significantly related to R (5‐19) in COPD participants without emphysema (ρ = 0.54, P = 0.008), and to X (5) in COPD participants with emphysema (ρ = −0.36, P = 0.04). A(X) was weakly related to VDP in asthma (ρ = 0.47, P = 0.0007) and COPD participants with (ρ = 0.39, P = 0.02) and without (ρ = 0.43, P = 0.04) emphysema. A(X) is sensitive to obstruction but not specific to the type of obstruction, whereas the different relationships for MRI VDP with R (5‐19) and X (5) may reflect the different airway and parenchymal disease‐specific biomechanical abnormalities that lead to ventilation defects. John Wiley and Sons Inc. 2019-01-10 /pmc/articles/PMC6328923/ /pubmed/30632309 http://dx.doi.org/10.14814/phy2.13955 Text en © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Eddy, Rachel L. Westcott, Andrew Maksym, Geoffrey N. Parraga, Grace Dandurand, Ronald J. Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD |
title | Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
|
title_full | Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
|
title_fullStr | Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
|
title_full_unstemmed | Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
|
title_short | Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
|
title_sort | oscillometry and pulmonary magnetic resonance imaging in asthma and copd |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328923/ https://www.ncbi.nlm.nih.gov/pubmed/30632309 http://dx.doi.org/10.14814/phy2.13955 |
work_keys_str_mv | AT eddyrachell oscillometryandpulmonarymagneticresonanceimaginginasthmaandcopd AT westcottandrew oscillometryandpulmonarymagneticresonanceimaginginasthmaandcopd AT maksymgeoffreyn oscillometryandpulmonarymagneticresonanceimaginginasthmaandcopd AT parragagrace oscillometryandpulmonarymagneticresonanceimaginginasthmaandcopd AT dandurandronaldj oscillometryandpulmonarymagneticresonanceimaginginasthmaandcopd |