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Addition of the C‐terminus of CD6 to a chimeric antigen receptor enhances cytotoxicity and does not compromise expression
T cells expressing chimeric antigen receptors (CARs) are a promising new cancer immunotherapy that has now reached the clinic. CARs are synthetic receptors that redirect T cells towards a tumour‐associated antigen and activate them through various fused signalling regions, for example derived from C...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328988/ https://www.ncbi.nlm.nih.gov/pubmed/30300924 http://dx.doi.org/10.1111/imm.13009 |