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Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis

Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, ta...

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Detalles Bibliográficos
Autores principales: Tudrej, Karol Borys, Piecha, Tomasz, Kozłowska-Wojciechowska, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329030/
https://www.ncbi.nlm.nih.gov/pubmed/30671141
http://dx.doi.org/10.1177/1756287218818030
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author Tudrej, Karol Borys
Piecha, Tomasz
Kozłowska-Wojciechowska, Małgorzata
author_facet Tudrej, Karol Borys
Piecha, Tomasz
Kozłowska-Wojciechowska, Małgorzata
author_sort Tudrej, Karol Borys
collection PubMed
description Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Identification of a novel mediator of bladder inflammation and pain could lead to emerging new therapeutic strategy and the first causative therapy.
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spelling pubmed-63290302019-01-22 Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis Tudrej, Karol Borys Piecha, Tomasz Kozłowska-Wojciechowska, Małgorzata Ther Adv Urol Review Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Identification of a novel mediator of bladder inflammation and pain could lead to emerging new therapeutic strategy and the first causative therapy. SAGE Publications 2019-01-08 /pmc/articles/PMC6329030/ /pubmed/30671141 http://dx.doi.org/10.1177/1756287218818030 Text en © The Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Tudrej, Karol Borys
Piecha, Tomasz
Kozłowska-Wojciechowska, Małgorzata
Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
title Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
title_full Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
title_fullStr Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
title_full_unstemmed Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
title_short Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
title_sort role of nlrp3 inflammasome in the development of bladder pain syndrome interstitial cystitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329030/
https://www.ncbi.nlm.nih.gov/pubmed/30671141
http://dx.doi.org/10.1177/1756287218818030
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