Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer

BACKGROUND: Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachment, thus murine cells are generally non-permissive for human adenoviral infect...

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Detalles Bibliográficos
Autores principales: De Carlo, Flavia, Thomas, Litty, Brooke, Bell, Varney, Elliot T., Nande, Rounak, Boskovic, Olivia, Marshall, Gailen D., Claudio, Pier Paolo, Howard, Candace M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329087/
https://www.ncbi.nlm.nih.gov/pubmed/30635014
http://dx.doi.org/10.1186/s12967-019-1771-0

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