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Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency
BACKGROUND: Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6 (Sirt6), a member of the sirtuin family of NAD(+)-dependent protein deacetylas...
Autores principales: | Xu, Peng, Wang, Ting-ting, Liu, Xiu-zhen, Wang, Nan-Yu, Sun, Li-hong, Zhang, Zhu-qin, Chen, Hou-zao, Lv, Xiang, Huang, Yue, Liu, De-Pei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329104/ https://www.ncbi.nlm.nih.gov/pubmed/30630525 http://dx.doi.org/10.1186/s13287-018-1109-5 |
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