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Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy

Angiotensin-converting enzyme (ACE) is the primary enzyme that converts angiotensin I (Ang I) to angiotensin II (Ang II) in the renin-angiotensin system (RAS). However, chymase hydrates Ang I to Ang II independently of ACE in some kidney diseases, and it may play an important role. The present study...

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Detalles Bibliográficos
Autores principales:	Hsieh, Wen-Yeh, Chang, Teng-Hsiang, Chang, Hui-Fang, Chuang, Wan-Hsuan, Lu, Li-Che, Yang, Chung-Wei, Lin, Chih-Sheng, Chang, Chia-Chu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329531/ https://www.ncbi.nlm.nih.gov/pubmed/30633770 http://dx.doi.org/10.1371/journal.pone.0210656

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