Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as...

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Detalles Bibliográficos
Autores principales: Sarhan, Joseph, Liu, Beiyun C., Muendlein, Hayley I., Weindel, Chi G., Smirnova, Irina, Tang, Amy Y., Ilyukha, Vladimir, Sorokin, Maxim, Buzdin, Anton, Fitzgerald, Katherine A., Poltorak, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329789/
https://www.ncbi.nlm.nih.gov/pubmed/29786074
http://dx.doi.org/10.1038/s41418-018-0122-7

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