Cargando…
The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
Cancer sequencing studies have implicated regulators of pre-mRNA splicing as important disease determinants in acute myeloid leukemia (AML), but the underlying mechanisms have remained elusive. We hypothesized that “non-mutated” splicing regulators may also play a role in AML biology and therefore c...
Autores principales: | Ge, Ying, Schuster, Mikkel Bruhn, Pundhir, Sachin, Rapin, Nicolas, Bagger, Frederik Otzen, Sidiropoulos, Nikos, Hashem, Nadia, Porse, Bo Torben |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329799/ https://www.ncbi.nlm.nih.gov/pubmed/30635567 http://dx.doi.org/10.1038/s41467-018-08076-y |
Ejemplares similares
-
Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality
por: Pundhir, Sachin, et al.
Publicado: (2016) -
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
por: Hansen, Anne Meldgaard, et al.
Publicado: (2022) -
BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis
por: Bagger, Frederik Otzen, et al.
Publicado: (2016) -
The ASXL1-G643Wvariant accelerates the development of CEBPA mutant acute myeloid leukemia
por: D’Altri, Teresa, et al.
Publicado: (2020) -
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
por: Trempenau, Mette Louise, et al.
Publicado: (2023)