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Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study

BACKGROUND: The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. OBJECTIVE: The objective of this study was to evaluate all major aspects of the NEDICES-2...

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Autores principales: Hernández-Gallego, Jesús, Llamas-Velasco, Sara, Bermejo-Pareja, Felix, Vega, Saturio, Tapias-Merino, Ester, Rodríguez-Sánchez, Emiliano, Boycheva, Elina, Serrano, José Ignacio, Gil-García, Juan-Francisco, Trincado, Rocio, Sánchez-Rodrigo, José-María Vizcaino, Cacho, Jesús, Contador, Israel, Garcia-Ptacek, Sara, Sierra-Hidalgo, Fernando, Cubo, Esther, Carro, Eva, Villarejo-Galende, Alberto, García García-Patino, Rosalía, Benito-León, Julián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329894/
https://www.ncbi.nlm.nih.gov/pubmed/30632964
http://dx.doi.org/10.2196/10941
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author Hernández-Gallego, Jesús
Llamas-Velasco, Sara
Bermejo-Pareja, Felix
Vega, Saturio
Tapias-Merino, Ester
Rodríguez-Sánchez, Emiliano
Boycheva, Elina
Serrano, José Ignacio
Gil-García, Juan-Francisco
Trincado, Rocio
Sánchez-Rodrigo, José-María Vizcaino
Cacho, Jesús
Contador, Israel
Garcia-Ptacek, Sara
Sierra-Hidalgo, Fernando
Cubo, Esther
Carro, Eva
Villarejo-Galende, Alberto
García García-Patino, Rosalía
Benito-León, Julián
author_facet Hernández-Gallego, Jesús
Llamas-Velasco, Sara
Bermejo-Pareja, Felix
Vega, Saturio
Tapias-Merino, Ester
Rodríguez-Sánchez, Emiliano
Boycheva, Elina
Serrano, José Ignacio
Gil-García, Juan-Francisco
Trincado, Rocio
Sánchez-Rodrigo, José-María Vizcaino
Cacho, Jesús
Contador, Israel
Garcia-Ptacek, Sara
Sierra-Hidalgo, Fernando
Cubo, Esther
Carro, Eva
Villarejo-Galende, Alberto
García García-Patino, Rosalía
Benito-León, Julián
author_sort Hernández-Gallego, Jesús
collection PubMed
description BACKGROUND: The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. OBJECTIVE: The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. METHODS: A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. RESULTS: In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. CONCLUSIONS: Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection).
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spelling pubmed-63298942019-02-11 Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study Hernández-Gallego, Jesús Llamas-Velasco, Sara Bermejo-Pareja, Felix Vega, Saturio Tapias-Merino, Ester Rodríguez-Sánchez, Emiliano Boycheva, Elina Serrano, José Ignacio Gil-García, Juan-Francisco Trincado, Rocio Sánchez-Rodrigo, José-María Vizcaino Cacho, Jesús Contador, Israel Garcia-Ptacek, Sara Sierra-Hidalgo, Fernando Cubo, Esther Carro, Eva Villarejo-Galende, Alberto García García-Patino, Rosalía Benito-León, Julián JMIR Res Protoc Original Paper BACKGROUND: The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. OBJECTIVE: The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. METHODS: A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. RESULTS: In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. CONCLUSIONS: Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection). JMIR Publications 2019-01-10 /pmc/articles/PMC6329894/ /pubmed/30632964 http://dx.doi.org/10.2196/10941 Text en ©Jesús Hernández-Gallego, Sara Llamas-Velasco, Felix Bermejo-Pareja, Saturio Vega, Ester Tapias-Merino, Emiliano Rodríguez-Sánchez, Elina Boycheva, José Ignacio Serrano, Juan-Francisco Gil-García, Rocio Trincado, José-María Vizcaino Sánchez-Rodrigo, Jesús Cacho, Israel Contador, Sara Garcia-Ptacek, Fernando Sierra-Hidalgo, Esther Cubo, Eva Carro, Alberto Villarejo-Galende, Rosalía García García-Patino, Julián Benito-León. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 10.01.2019. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.
spellingShingle Original Paper
Hernández-Gallego, Jesús
Llamas-Velasco, Sara
Bermejo-Pareja, Felix
Vega, Saturio
Tapias-Merino, Ester
Rodríguez-Sánchez, Emiliano
Boycheva, Elina
Serrano, José Ignacio
Gil-García, Juan-Francisco
Trincado, Rocio
Sánchez-Rodrigo, José-María Vizcaino
Cacho, Jesús
Contador, Israel
Garcia-Ptacek, Sara
Sierra-Hidalgo, Fernando
Cubo, Esther
Carro, Eva
Villarejo-Galende, Alberto
García García-Patino, Rosalía
Benito-León, Julián
Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
title Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
title_full Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
title_fullStr Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
title_full_unstemmed Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
title_short Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study
title_sort neurological disorders in central spain, second survey: feasibility pilot observational study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329894/
https://www.ncbi.nlm.nih.gov/pubmed/30632964
http://dx.doi.org/10.2196/10941
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