Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling...

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Detalles Bibliográficos
Autores principales: Zadra, Giorgia, Ribeiro, Caroline F., Chetta, Paolo, Ho, Yeung, Cacciatore, Stefano, Gao, Xueliang, Syamala, Sudeepa, Bango, Clyde, Photopoulos, Cornelia, Huang, Ying, Tyekucheva, Svitlana, Bastos, Debora C., Tchaicha, Jeremy, Lawney, Brian, Uo, Takuma, D’Anello, Laura, Csibi, Alfredo, Kalekar, Radha, Larimer, Benjamin, Ellis, Leigh, Butler, Lisa M., Morrissey, Colm, McGovern, Karen, Palombella, Vito J., Kutok, Jeffery L., Mahmood, Umar, Bosari, Silvano, Adams, Julian, Peluso, Stephane, Dehm, Scott M., Plymate, Stephen R., Loda, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329966/
https://www.ncbi.nlm.nih.gov/pubmed/30578319
http://dx.doi.org/10.1073/pnas.1808834116

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