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Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity

Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin lymphoma with a poor prognosis and high recurrence rate. It seldom affects the Waldeyer’s ring let alone the nasopharynx. Patients usually present at late stages of the disease leading to poor failure-free and overall survival r...

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Autores principales: Paul, Mark, Asmi, Najihah Hanim, Omar, Eshamsol Kamar, Abdullah, Suhaila, Mohamad, Irfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330188/
https://www.ncbi.nlm.nih.gov/pubmed/30671189
http://dx.doi.org/10.5001/omj.2019.13
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author Paul, Mark
Asmi, Najihah Hanim
Omar, Eshamsol Kamar
Abdullah, Suhaila
Mohamad, Irfan
author_facet Paul, Mark
Asmi, Najihah Hanim
Omar, Eshamsol Kamar
Abdullah, Suhaila
Mohamad, Irfan
author_sort Paul, Mark
collection PubMed
description Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin lymphoma with a poor prognosis and high recurrence rate. It seldom affects the Waldeyer’s ring let alone the nasopharynx. Patients usually present at late stages of the disease leading to poor failure-free and overall survival rates. Intensive chemotherapy regimes and autologous stem cell transplantation have reported increased survival rates. We report a relapsed case of nasopharyngeal MCL, which previously occurred in the gastrointestinal tract. The patient had undergone a hemicolectomy for colon intussusception secondary to the intraluminal lymphoma mass. He was unable to complete the treatment regime for MCL due to the adverse side effects. Oropharyngeal mass was discovered during routine outpatient follow-up, which was confirmed as nasopharyngeal MCL. We discuss the prognosis, disease progression, and possible treatments.
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spelling pubmed-63301882019-01-22 Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity Paul, Mark Asmi, Najihah Hanim Omar, Eshamsol Kamar Abdullah, Suhaila Mohamad, Irfan Oman Med J Case Report Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin lymphoma with a poor prognosis and high recurrence rate. It seldom affects the Waldeyer’s ring let alone the nasopharynx. Patients usually present at late stages of the disease leading to poor failure-free and overall survival rates. Intensive chemotherapy regimes and autologous stem cell transplantation have reported increased survival rates. We report a relapsed case of nasopharyngeal MCL, which previously occurred in the gastrointestinal tract. The patient had undergone a hemicolectomy for colon intussusception secondary to the intraluminal lymphoma mass. He was unable to complete the treatment regime for MCL due to the adverse side effects. Oropharyngeal mass was discovered during routine outpatient follow-up, which was confirmed as nasopharyngeal MCL. We discuss the prognosis, disease progression, and possible treatments. OMJ 2019-01 /pmc/articles/PMC6330188/ /pubmed/30671189 http://dx.doi.org/10.5001/omj.2019.13 Text en The OMJ is Published Bimonthly and Copyrighted 2019 by the OMSB. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). ( https://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Case Report
Paul, Mark
Asmi, Najihah Hanim
Omar, Eshamsol Kamar
Abdullah, Suhaila
Mohamad, Irfan
Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity
title Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity
title_full Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity
title_fullStr Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity
title_full_unstemmed Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity
title_short Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity
title_sort nasopharyngeal mantle cell lymphoma: an extremely rare entity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330188/
https://www.ncbi.nlm.nih.gov/pubmed/30671189
http://dx.doi.org/10.5001/omj.2019.13
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