Cargando…

Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Na(v)1.8 β1 Subunit of Sensory Neurons

Currently there is no effective treatment available for clinical patients suffering from neuropathic pain induced by chemotherapy paclitaxel. Puerarin is a major isoflavonoid extracted from the Chinese medical herb kudzu root, which has been used for treatment of cardiovascular disorders and brain i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiao-Long, Cao, Xian-Ying, Lai, Ren-Chun, Xie, Man-Xiu, Zeng, Wei-An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330330/ https://www.ncbi.nlm.nih.gov/pubmed/30666203 http://dx.doi.org/10.3389/fphar.2018.01510

Ejemplares similares

Regulatory Role of Voltage-Gated Na(+) Channel β Subunits in Sensory Neurons
por: Chahine, Mohamed, et al.
Publicado: (2011)

Transcriptomic Profiling in Mice With CB1 receptor Deletion in Primary Sensory Neurons Suggests New Analgesic Targets for Neuropathic Pain
por: Liu, Yongmin, et al.
Publicado: (2022)

Cold sensing by Na(V)1.8-positive and Na(V)1.8-negative sensory neurons
por: Luiz, A. P., et al.
Publicado: (2019)

Puerarin: A protective drug against ischemia-reperfusion injury
por: Gao, Minglang, et al.
Publicado: (2022)

Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases
por: Zhou, Yan-Xi, et al.
Publicado: (2021)

Effect of Puerarin Regulated mTOR Signaling Pathway in Experimental Liver Injury
por: Zhou, Bu-Gao, et al.
Publicado: (2018)

Molecular Mechanism of Puerarin Against Diabetes and its Complications
por: Bai, Yi-ling, et al.
Publicado: (2022)

Integrating network pharmacology and experimental verification to explore the mechanism of puerarin against oliguria in acute alcoholism
por: Wan, Mei-Xuan, et al.
Publicado: (2022)

Neuropathic Injury–Induced Plasticity of GABAergic System in Peripheral Sensory Ganglia
por: Wang, Caixue, et al.
Publicado: (2021)

The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain
por: Park, Keun-Tae, et al.
Publicado: (2023)

Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis
por: Yang, Chao, et al.
Publicado: (2019)

The Calcium Channel α2δ1 Subunit: Interactional Targets in Primary Sensory Neurons and Role in Neuropathic Pain
por: Cui, Wenqiang, et al.
Publicado: (2021)

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats
por: Cai, Shao-Ai, et al.
Publicado: (2018)

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord
por: Liu, Ming, et al.
Publicado: (2014)

Na(+) Channel β Subunits: Overachievers of the Ion Channel Family
por: Brackenbury, William J., et al.
Publicado: (2011)

Puerarin inhibits EMT induced by oxaliplatin via targeting carbonic anhydrase XII
por: Chen, Xindong, et al.
Publicado: (2022)

Chemogenetic Silencing of Na(V)1.8-Positive Sensory Neurons Reverses Chronic Neuropathic and Bone Cancer Pain in FLEx PSAM(4)-GlyR Mice
por: Haroun, Rayan, et al.
Publicado: (2023)

Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
por: Yin, Zhihui, et al.
Publicado: (2021)

Puerarin Ameliorates Caerulein-Induced Chronic Pancreatitis via Inhibition of MAPK Signaling Pathway
por: Zeng, Xiang-Peng, et al.
Publicado: (2021)

Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in Sensory Neurons
por: Li, Yuanyuan, et al.
Publicado: (2019)

Medial septum glutamatergic neurons modulate nociception in chronic neuropathic pain via projections to lateral hypothalamus
por: Fan, Bing-Qian, et al.
Publicado: (2023)

Na(V)1.8 channels are expressed in large, as well as small, diameter sensory afferent neurons
por: Ramachandra, Renuka, et al.
Publicado: (2013)

Putting a Pause on Pain: Chemogenetic Silencing of NaV1.8-Positive Sensory Neurons
por: Nippert, Amy R.
Publicado: (2023)

Paclitaxel effects on axonal localization and vesicular trafficking of Na(V)1.8
por: Baker, Christopher A., et al.
Publicado: (2023)

Puerarin Prevents Acute Liver Injury via Inhibiting Inflammatory Responses and ZEB2 Expression
por: Yang, Junfa, et al.
Publicado: (2021)

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8
por: Nassar, Mohammed A, et al.
Publicado: (2005)

Acidosis Differentially Modulates Inactivation in Na(V)1.2, Na(V)1.4, and Na(V)1.5 Channels
por: Vilin, Yury Y., et al.
Publicado: (2012)

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway
por: Zhang, Qianqian, et al.
Publicado: (2023)

Goshajinkigan attenuates paclitaxel‐induced neuropathic pain via cortical astrocytes
por: Takanashi, Kenta, et al.
Publicado: (2021)

ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans
por: Yu, Xiaobing, et al.
Publicado: (2023)

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases
por: Wang, Qian, et al.
Publicado: (2022)

A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line
por: Zhou, Xi, et al.
Publicado: (2018)

TMI-1, TNF-α-Converting Enzyme Inhibitor, Protects Against Paclitaxel-Induced Neurotoxicity in the DRG Neuronal Cells In Vitro
por: Kim, Yesul, et al.
Publicado: (2022)

Hemokinin-1 as a Mediator of Arthritis-Related Pain via Direct Activation of Primary Sensory Neurons
por: Borbély, Éva, et al.
Publicado: (2021)

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain
por: Kwon, Minjee, et al.
Publicado: (2021)

A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance
por: Giacoletti, Gianna, et al.
Publicado: (2022)

Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide‐binding protein Gi subunit alpha‐1 (Gnai1) subunit
por: Zhu, Qingqing, et al.
Publicado: (2022)

Acetaminophen: Beyond Pain and Fever-Relieving
por: Blough, Eric R., et al.
Publicado: (2011)

MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons
por: Ma, Longfei, et al.
Publicado: (2021)

Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain
por: Carcolé, Mireia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_or5ftmge5oj7dlij4f5vsd6gss