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Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

BACKGROUND: Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown. RESULTS: Here we investigated the pathophysiological function of...

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Autores principales: Yu, Zheng, Lin, Dong, Zhong, Yanzi, Luo, Bin, Liu, Shengsheng, Fei, Erkang, Lai, Xinsheng, Zou, Suqi, Wang, Shunqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330398/
https://www.ncbi.nlm.nih.gov/pubmed/30651970
http://dx.doi.org/10.1186/s13578-019-0272-4
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author Yu, Zheng
Lin, Dong
Zhong, Yanzi
Luo, Bin
Liu, Shengsheng
Fei, Erkang
Lai, Xinsheng
Zou, Suqi
Wang, Shunqi
author_facet Yu, Zheng
Lin, Dong
Zhong, Yanzi
Luo, Bin
Liu, Shengsheng
Fei, Erkang
Lai, Xinsheng
Zou, Suqi
Wang, Shunqi
author_sort Yu, Zheng
collection PubMed
description BACKGROUND: Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown. RESULTS: Here we investigated the pathophysiological function of Tmem108 in the hippocampal dentate gyrus by using Tmem108 mutant mice. Tmem108 highly expressed in the dentate gyrus and CA3 of the hippocampus. Dentate gyrus is a brain region where adult neurogenesis occurs, and aberrant adult neurogenesis in dentate gyrus has been implicated in major depression disorder. Indeed, Tmem108 mutant mice had lower immobility than wild type mice in tail suspension test and forced swimming test. BrdU and anti-Ki67 antibody staining indicated that adult neurogenesis of the hippocampal dentate gyrus region decreased in Tmem108 mutant mice. qPCR results showed that expression of Axin2, DISC1 and β-Catenin, three dentate gyrus adult neurogenesis related genes in Wnt/β-Catenin signaling pathway, decreased in Tmem108 mutant mice. Furthermore, Tmem108 enhanced free β-Catenin level in dual luciferase assay. CONCLUSIONS: Thus, our data suggest that Tmem108 increases adult neurogenesis and plays a complexity role in psychiatric disorders.
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spelling pubmed-63303982019-01-16 Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus Yu, Zheng Lin, Dong Zhong, Yanzi Luo, Bin Liu, Shengsheng Fei, Erkang Lai, Xinsheng Zou, Suqi Wang, Shunqi Cell Biosci Research BACKGROUND: Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown. RESULTS: Here we investigated the pathophysiological function of Tmem108 in the hippocampal dentate gyrus by using Tmem108 mutant mice. Tmem108 highly expressed in the dentate gyrus and CA3 of the hippocampus. Dentate gyrus is a brain region where adult neurogenesis occurs, and aberrant adult neurogenesis in dentate gyrus has been implicated in major depression disorder. Indeed, Tmem108 mutant mice had lower immobility than wild type mice in tail suspension test and forced swimming test. BrdU and anti-Ki67 antibody staining indicated that adult neurogenesis of the hippocampal dentate gyrus region decreased in Tmem108 mutant mice. qPCR results showed that expression of Axin2, DISC1 and β-Catenin, three dentate gyrus adult neurogenesis related genes in Wnt/β-Catenin signaling pathway, decreased in Tmem108 mutant mice. Furthermore, Tmem108 enhanced free β-Catenin level in dual luciferase assay. CONCLUSIONS: Thus, our data suggest that Tmem108 increases adult neurogenesis and plays a complexity role in psychiatric disorders. BioMed Central 2019-01-11 /pmc/articles/PMC6330398/ /pubmed/30651970 http://dx.doi.org/10.1186/s13578-019-0272-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yu, Zheng
Lin, Dong
Zhong, Yanzi
Luo, Bin
Liu, Shengsheng
Fei, Erkang
Lai, Xinsheng
Zou, Suqi
Wang, Shunqi
Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
title Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
title_full Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
title_fullStr Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
title_full_unstemmed Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
title_short Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
title_sort transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330398/
https://www.ncbi.nlm.nih.gov/pubmed/30651970
http://dx.doi.org/10.1186/s13578-019-0272-4
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