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Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis

BACKGROUND: Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1...

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Detalles Bibliográficos
Autores principales:	Trellu, Sabine, Courties, Alice, Jaisson, Stéphane, Gorisse, Laëtitia, Gillery, Philippe, Kerdine-Römer, Saadia, Vaamonde-Garcia, Carlos, Houard, Xavier, Ekhirch, François-Paul, Sautet, Alain, Friguet, Bertrand, Jacques, Claire, Berenbaum, Francis, Sellam, Jérémie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330409/ https://www.ncbi.nlm.nih.gov/pubmed/30635030 http://dx.doi.org/10.1186/s13075-018-1801-y

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