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An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

BACKGROUND: Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymatrine, cy...

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Detalles Bibliográficos
Autores principales:	Wang, Ruiying, Wang, Min, Wang, Shan, Yang, Ke, Zhou, Ping, Xie, Xueheng, Cheng, Qi, Ye, Jingxue, Sun, Guibo, Sun, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330446/ https://www.ncbi.nlm.nih.gov/pubmed/30635051 http://dx.doi.org/10.1186/s13287-018-1126-4

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