NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB

BACKGROUND: NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inflammasome inhibitor, MCC950, to investigate whether it inhibited liver fibrosis, and explored the preliminary molecular mechanism. METHODS: BAL...

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Detalles Bibliográficos
Autores principales: Zhang, Wen-Juan, Fang, Zheng-Ming, Liu, Wen-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330481/
https://www.ncbi.nlm.nih.gov/pubmed/30635040
http://dx.doi.org/10.1186/s13071-018-3223-8

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