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Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic myeloid malignancy that is known to be derived from plasmacytoid dendritic cells which are characterized by expression of CD4, CD56, and more specific markers such as CD123. Here, the authors present three cases of BPDCN dia...

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Autores principales: Safaei, Akbar, Monabati, Ahmad, Mokhtari, Maral, Solhjoo, Freidoon, Montazer, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330528/
https://www.ncbi.nlm.nih.gov/pubmed/30666080
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author Safaei, Akbar
Monabati, Ahmad
Mokhtari, Maral
Solhjoo, Freidoon
Montazer, Mehdi
author_facet Safaei, Akbar
Monabati, Ahmad
Mokhtari, Maral
Solhjoo, Freidoon
Montazer, Mehdi
author_sort Safaei, Akbar
collection PubMed
description Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic myeloid malignancy that is known to be derived from plasmacytoid dendritic cells which are characterized by expression of CD4, CD56, and more specific markers such as CD123. Here, the authors present three cases of BPDCN diagnosed in the past two years and address different available diagnostic modalities such as morphology, immunohistochemistry, flow cytometry, and cytogenetics. Overall, we believe that although BPDCN is a rare diagnosis, it should not be left unchecked. Currently, available immunophenotyping markers are of great help, but the main clue to figure out the problem of BPDCN is clinicopathologic suspicion.
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spelling pubmed-63305282019-01-21 Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases Safaei, Akbar Monabati, Ahmad Mokhtari, Maral Solhjoo, Freidoon Montazer, Mehdi Iran J Med Sci Case Reports Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic myeloid malignancy that is known to be derived from plasmacytoid dendritic cells which are characterized by expression of CD4, CD56, and more specific markers such as CD123. Here, the authors present three cases of BPDCN diagnosed in the past two years and address different available diagnostic modalities such as morphology, immunohistochemistry, flow cytometry, and cytogenetics. Overall, we believe that although BPDCN is a rare diagnosis, it should not be left unchecked. Currently, available immunophenotyping markers are of great help, but the main clue to figure out the problem of BPDCN is clinicopathologic suspicion. Iranian Journal of Medical Sciences 2019-01 /pmc/articles/PMC6330528/ /pubmed/30666080 Text en Copyright: © Iranian Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Safaei, Akbar
Monabati, Ahmad
Mokhtari, Maral
Solhjoo, Freidoon
Montazer, Mehdi
Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
title Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
title_full Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
title_fullStr Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
title_full_unstemmed Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
title_short Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases
title_sort blastic plasmacytoid dendritic cell neoplasm; a report of three cases
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330528/
https://www.ncbi.nlm.nih.gov/pubmed/30666080
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