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Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans
We investigated whether heat‐induced hyperventilation can be voluntarily prevented, and, if so, how this modulates respiratory mechanics and cerebral blood flow in resting heated humans. In two separate trials, 10 healthy men were passively heated using lower body hot‐water immersion and a water‐per...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330649/ https://www.ncbi.nlm.nih.gov/pubmed/30637992 http://dx.doi.org/10.14814/phy2.13967 |
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author | Tsuji, Bun Hoshi, Yuta Honda, Yasushi Fujii, Naoto Sasaki, Yosuke Cheung, Stephen S. Kondo, Narihiko Nishiyasu, Takeshi |
author_facet | Tsuji, Bun Hoshi, Yuta Honda, Yasushi Fujii, Naoto Sasaki, Yosuke Cheung, Stephen S. Kondo, Narihiko Nishiyasu, Takeshi |
author_sort | Tsuji, Bun |
collection | PubMed |
description | We investigated whether heat‐induced hyperventilation can be voluntarily prevented, and, if so, how this modulates respiratory mechanics and cerebral blood flow in resting heated humans. In two separate trials, 10 healthy men were passively heated using lower body hot‐water immersion and a water‐perfused garment covering their upper body (both 41°C) until esophageal temperature (T (es)) reached 39°C or volitional termination. In each trial, participants breathed normally (normal‐breathing) or voluntarily controlled minute ventilation (V (E)) at a level equivalent to that observed after 5 min of heating (controlled‐breathing). Respiratory gases, middle cerebral artery blood velocity (MCAV), work of breathing, and end‐expiratory and inspiratory lung volumes were measured. During normal‐breathing, V (E) increased as T (es) rose above 38.0 ± 0.3°C, whereas controlled‐breathing diminished the increase in V (E) (V (E) at T (es) = 38.6°C: 25.6 ± 5.9 and 11.9 ± 1.3 L min(−1) during normal‐ and controlled‐breathing, respectively, P < 0.001). During normal‐breathing, end‐tidal CO(2) pressure and MCAV decreased with rising T (es), but controlled‐breathing diminished these reductions (at T (es) = 38.6°C, 24.7 ± 5.0 vs. 39.5 ± 2.8 mmHg; 44.9 ± 5.9 vs. 60.2 ± 6.3 cm sec(−1), both P < 0.001). The work of breathing correlated positively with changes in V (E) (P < 0.001) and was lower during controlled‐ than normal‐breathing (16.1 ± 12.6 and 59.4 ± 49.5 J min(−1), respectively, at heating termination, P = 0.013). End‐expiratory and inspiratory lung volumes did not differ between trials (P = 0.25 and 0.71, respectively). These results suggest that during passive heating at rest, heat‐induced hyperventilation increases the work of breathing without affecting end‐expiratory lung volume, and that voluntary control of breathing can nearly abolish this hyperventilation, thereby diminishing hypocapnia, cerebral hypoperfusion, and increased work of breathing. |
format | Online Article Text |
id | pubmed-6330649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63306492019-01-17 Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans Tsuji, Bun Hoshi, Yuta Honda, Yasushi Fujii, Naoto Sasaki, Yosuke Cheung, Stephen S. Kondo, Narihiko Nishiyasu, Takeshi Physiol Rep Original Research We investigated whether heat‐induced hyperventilation can be voluntarily prevented, and, if so, how this modulates respiratory mechanics and cerebral blood flow in resting heated humans. In two separate trials, 10 healthy men were passively heated using lower body hot‐water immersion and a water‐perfused garment covering their upper body (both 41°C) until esophageal temperature (T (es)) reached 39°C or volitional termination. In each trial, participants breathed normally (normal‐breathing) or voluntarily controlled minute ventilation (V (E)) at a level equivalent to that observed after 5 min of heating (controlled‐breathing). Respiratory gases, middle cerebral artery blood velocity (MCAV), work of breathing, and end‐expiratory and inspiratory lung volumes were measured. During normal‐breathing, V (E) increased as T (es) rose above 38.0 ± 0.3°C, whereas controlled‐breathing diminished the increase in V (E) (V (E) at T (es) = 38.6°C: 25.6 ± 5.9 and 11.9 ± 1.3 L min(−1) during normal‐ and controlled‐breathing, respectively, P < 0.001). During normal‐breathing, end‐tidal CO(2) pressure and MCAV decreased with rising T (es), but controlled‐breathing diminished these reductions (at T (es) = 38.6°C, 24.7 ± 5.0 vs. 39.5 ± 2.8 mmHg; 44.9 ± 5.9 vs. 60.2 ± 6.3 cm sec(−1), both P < 0.001). The work of breathing correlated positively with changes in V (E) (P < 0.001) and was lower during controlled‐ than normal‐breathing (16.1 ± 12.6 and 59.4 ± 49.5 J min(−1), respectively, at heating termination, P = 0.013). End‐expiratory and inspiratory lung volumes did not differ between trials (P = 0.25 and 0.71, respectively). These results suggest that during passive heating at rest, heat‐induced hyperventilation increases the work of breathing without affecting end‐expiratory lung volume, and that voluntary control of breathing can nearly abolish this hyperventilation, thereby diminishing hypocapnia, cerebral hypoperfusion, and increased work of breathing. John Wiley and Sons Inc. 2019-01-13 /pmc/articles/PMC6330649/ /pubmed/30637992 http://dx.doi.org/10.14814/phy2.13967 Text en © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Tsuji, Bun Hoshi, Yuta Honda, Yasushi Fujii, Naoto Sasaki, Yosuke Cheung, Stephen S. Kondo, Narihiko Nishiyasu, Takeshi Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
title | Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
title_full | Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
title_fullStr | Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
title_full_unstemmed | Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
title_short | Respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
title_sort | respiratory mechanics and cerebral blood flow during heat‐induced hyperventilation and its voluntary suppression in passively heated humans |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330649/ https://www.ncbi.nlm.nih.gov/pubmed/30637992 http://dx.doi.org/10.14814/phy2.13967 |
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