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Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques
Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for n...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330711/ https://www.ncbi.nlm.nih.gov/pubmed/30666300 http://dx.doi.org/10.3389/fcimb.2018.00440 |
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author | Petit, Marine J. Shah, Priya S. |
author_facet | Petit, Marine J. Shah, Priya S. |
author_sort | Petit, Marine J. |
collection | PubMed |
description | Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses and non-model organisms. Advances in systems biology “-omics”-based techniques such as next-generation sequencing (NGS) and mass spectrometry can rapidly provide an unbiased view of arbovirus-vector interaction landscapes. In this mini-review, we discuss how arbovirus-vector interaction studies have been advanced by systems biology. We review studies of arbovirus-vector interactions that occur at multiple time and length scales, including intracellular interactions, interactions at the level of the organism, viral and vector populations, and how new techniques can integrate systems-level data across these different scales. |
format | Online Article Text |
id | pubmed-6330711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63307112019-01-21 Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques Petit, Marine J. Shah, Priya S. Front Cell Infect Microbiol Cellular and Infection Microbiology Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses and non-model organisms. Advances in systems biology “-omics”-based techniques such as next-generation sequencing (NGS) and mass spectrometry can rapidly provide an unbiased view of arbovirus-vector interaction landscapes. In this mini-review, we discuss how arbovirus-vector interaction studies have been advanced by systems biology. We review studies of arbovirus-vector interactions that occur at multiple time and length scales, including intracellular interactions, interactions at the level of the organism, viral and vector populations, and how new techniques can integrate systems-level data across these different scales. Frontiers Media S.A. 2019-01-07 /pmc/articles/PMC6330711/ /pubmed/30666300 http://dx.doi.org/10.3389/fcimb.2018.00440 Text en Copyright © 2019 Petit and Shah. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Petit, Marine J. Shah, Priya S. Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title | Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_full | Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_fullStr | Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_full_unstemmed | Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_short | Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_sort | mapping arbovirus-vector interactions using systems biology techniques |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330711/ https://www.ncbi.nlm.nih.gov/pubmed/30666300 http://dx.doi.org/10.3389/fcimb.2018.00440 |
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