Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar

BACKGROUNDS/OBJECTIVES: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their pot...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Tahlawi, Samar, Ezzat Mohammad, Noha, Mohamed El-Amir, Azza, Sayed Mohamed, Heba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330724/
https://www.ncbi.nlm.nih.gov/pubmed/30675395
http://dx.doi.org/10.1177/2059513118818031
Descripción
Sumario:BACKGROUNDS/OBJECTIVES: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar. METHODS: Serum survivin and IGF-I levels were estimated in 30 patients with acne and post-acne scar compared to 30 controls. RESULTS: There was a statistically significant difference in survivin and IGF-I levels between controls and patients (P < 0.05). However, there was no linear correlation between survivin and IGF-I. CONCLUSIONS: Survivin and IGF-I could have a possible role in the pathogenesis of active acne and in post-inflammatory acne scar.

Ejemplares similares