SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker

Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and...

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Autores principales: Xu, Liyun, Lu, Changchang, Huang, Yanyan, Zhou, Jihang, Wang, Xincheng, Liu, Chaowu, Chen, Jun, Le, Hanbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330943/
https://www.ncbi.nlm.nih.gov/pubmed/30545439
http://dx.doi.org/10.5483/BMBRep.2018.51.12.205
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author Xu, Liyun
Lu, Changchang
Huang, Yanyan
Zhou, Jihang
Wang, Xincheng
Liu, Chaowu
Chen, Jun
Le, Hanbo
author_facet Xu, Liyun
Lu, Changchang
Huang, Yanyan
Zhou, Jihang
Wang, Xincheng
Liu, Chaowu
Chen, Jun
Le, Hanbo
author_sort Xu, Liyun
collection PubMed
description Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12.
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spelling pubmed-63309432019-01-22 SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker Xu, Liyun Lu, Changchang Huang, Yanyan Zhou, Jihang Wang, Xincheng Liu, Chaowu Chen, Jun Le, Hanbo BMB Rep Articles Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12. Korean Society for Biochemistry and Molecular Biology 2018-12 2018-12-31 /pmc/articles/PMC6330943/ /pubmed/30545439 http://dx.doi.org/10.5483/BMBRep.2018.51.12.205 Text en Copyright © 2018 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Xu, Liyun
Lu, Changchang
Huang, Yanyan
Zhou, Jihang
Wang, Xincheng
Liu, Chaowu
Chen, Jun
Le, Hanbo
SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
title SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
title_full SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
title_fullStr SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
title_full_unstemmed SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
title_short SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
title_sort spink1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330943/
https://www.ncbi.nlm.nih.gov/pubmed/30545439
http://dx.doi.org/10.5483/BMBRep.2018.51.12.205
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